The term peptic ulcer is used to describe any localised erosion of the mucosal lining of those portions of the alimentary tract that come in contact with gastric juice. The majority of ulcers are found in the duodenum, although they also occur in the oesophagus, stomach or jejunum. Usually there is a balance between acid pepsin secretion and mucosal resistance. As a result of excess acid production or weakening in the integrity of the stomach membrane or both, the mucosal lining is broken and the underlying layers of the stomach are exposed to the effect of the concentrated acid resulting in peptic ulcer.
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